What hormone causes Cushing’s?

Cushing’s syndrome, including Cushing’s disease, is primarily caused by the excessive production or administration of cortisol, a hormone produced by the adrenal glands.

In normal circumstances, cortisol plays important roles in regulating metabolism, immune function, stress response, blood sugar levels, and blood pressure. However, when cortisol levels become elevated for an extended period, it can lead to various symptoms and complications associated with Cushing’s syndrome.

The primary hormone involved in the development of Cushing’s disease, specifically, is adrenocorticotropic hormone (ACTH). ACTH is produced by the anterior pituitary gland, which is a small gland located at the base of the brain. ACTH stimulates the adrenal glands, which are situated on top of the kidneys, to produce cortisol.

In the case of Cushing’s disease, a benign tumor called an adenoma develops in the pituitary gland, leading to excessive secretion of ACTH. The increased ACTH levels then stimulate the adrenal glands to produce and release excessive amounts of cortisol, resulting in the symptoms and complications associated with Cushing’s syndrome.

It’s important to note that Cushing’s syndrome can also occur due to other causes, such as adrenal tumors that directly produce cortisol (referred to as adrenal Cushing’s syndrome) or the prolonged use of corticosteroid medications (referred to as exogenous Cushing’s syndrome). In these cases, the excess cortisol is not primarily caused by ACTH overproduction but rather by other factors.

Diagnosing the specific cause of Cushing’s syndrome requires thorough evaluation by healthcare professionals, including hormonal testing, imaging studies, and sometimes additional procedures to determine the underlying source of cortisol excess.

People Are Reading:  What are 3 risk factors for cholecystitis?

If you suspect you have Cushing’s syndrome or have concerns about cortisol levels, it is important to consult with an endocrinologist or healthcare professional experienced in the diagnosis and treatment of hormonal disorders for proper evaluation and management.