Which antihistamine drugs treat angioedema?

Antihistamines are commonly used to help alleviate the symptoms of angioedema. The specific antihistamine medications that may be prescribed to treat angioedema include:

  1. First-generation Antihistamines: First-generation antihistamines, such as diphenhydramine (Benadryl), chlorpheniramine, or hydroxyzine, can help reduce itching, swelling, and allergic reactions associated with angioedema. These medications are readily available over-the-counter and may cause drowsiness as a side effect.
  2. Second-generation Antihistamines: Second-generation antihistamines, such as cetirizine (Zyrtec), loratadine (Claritin), fexofenadine (Allegra), and desloratadine (Clarinex), are also effective in managing angioedema. These medications tend to have less sedating effects compared to first-generation antihistamines.

Both first-generation and second-generation antihistamines work by blocking the effects of histamine, a chemical released during allergic reactions that contributes to swelling and itching in angioedema.

It’s important to note that while antihistamines can help alleviate symptoms, they may not be sufficient for severe or life-threatening cases of angioedema. In such situations, immediate medical attention is necessary, and treatments like epinephrine (adrenaline) and corticosteroids may be required.

Always consult with a healthcare professional, such as an allergist or immunologist, who can evaluate your specific situation and provide appropriate treatment recommendations for managing angioedema.

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